PCL covered PP meshes plasma-grafted by sulfonated monomer for the prevention of postoperative abdominal adhesions

Abdominal hernia reparation constitutes the second surgical operation in world with more than 20 million cases per year. However, 50 % of all intra-abdominal operations, postoperative adhesions occur and result important pain for patients. These take place after excessive deposition fibrin between peritoneum organs within 7 days which occurs during coagulation cascade. For this reason, therapeutic solutions are required to both prevent adhesion limit need a step. Numerous techniques were described past few decades design biomedical textile implants and, among them, electrospinning shows great interest due porous nanometer diameter range structure obtained fibers. In parallel, cold plasma treatment can be used activate graft their surface functional molecules, exhibiting example antibacterial or anticoagulant properties. This work aims at functionalizing, biodegradable polycaprolactone (PCL) electrospun nanofibers covering polypropylene meshes (PPM) 2-acrylamido-2-methylpropane sulfonic acid (AMPS) through induced copolymerization. AMPS was chosen as it contains heparin-like segments, leading potentially similar effect. First, PCL optimized by varying process, solution environmental parameters allowed select 12 formic/acetic mixture. The graft-copolymerization then terms power time treatment, well concentration, using experimental design, order obtain rich SO3H groups surface. At each step material thoroughly characterized proving presence onto nanofibers. cytocompatibility properties, evaluated sterilization, promising an anti-adhesive application these nanofibrous mats no release cytotoxic compound.